CICAPLAST BAUME B5TRAINING FILEMaggie LiaoNov, 2013Agenda Skinwound Thehealingprocess CICAPLASTBAUMEB5•••••••••CICAPLAST RangePositioningComparisonIngredient chartKey ingredient & benefitProduct efficacy & toleranceObservational studyMinimalist formula & TextureKey ingredient & benefitProduct efficacy & tolerance CICAPLASTGELSKIN WOUND定義 何謂傷口？人體的皮膚組織一旦遭受到破壞，不管是源自於外力傷害、慢性發炎病症造成、醫美手術等，都會在身上形成傷口。而傷口一旦形成，人的表皮會竭盡所能的來使傷口癒合傷口與疤痕當我們的皮膚發生傷口後，組織自然會進行止血發炎期、肉芽生長期、上皮生長期、疤痕重塑期，四個階段來修復 若前三個階段進行不順利，將會延緩傷口的癒合。若疤痕重塑期持續過久，則會造成疤痕增生 一般於兩週內癒合的傷口，多不會留下疤痕，超過三週才癒合的的傷口，則可能留下明顯的痕跡關鍵在於傷口發生後，提供傷口良好癒合環境，以促進傷口癒合速度，避免疤痕產生傷口的類型依傷口深度 2typesdependingofthedepthintheskin:表皮層EPIDERMAL Lesions“任何沒有流血的病灶或傷口”表皮性的傷口真皮層DERMAL Lesions“任何有流血的病灶或傷口”真皮性的傷口傷口的類型依傷口成因1適應症日常偶發性傷口及不適2慢性發炎傷口3Post-procedure術後傷口DailyinjuriesChronicskin wound皮膚灼熱.乾燥.搔癢.粗糙;濕疹; 異位性皮膚炎; 皮膚皮膚龜裂.裂紋; 蚊蟲咬; 擦.乾燥症; 尿布疹;切. 劃. 曬傷; 泡疹; 日光性脂漏性皮膚炎; 乾癬皮膚炎自我診斷/藥師皮膚科醫師/藥師雷射手術後; 換膚後; 脈衝光後; 磨皮後, 電波拉皮後;冷凍治療後諮詢對象皮膚科醫師/藥師價格接受度THE HEALING PROCESS傷口癒合四階段DAY 60+傷口程度較表淺傷口程度較深層1st stage:Cleansing the wound止血發炎期紅腫水腫局部疼痛2nd stage:Granulation肉芽生長期3rd stage:Epithelialization上皮生長期4th stage:Remodeling疤痕重塑期傷口先止血傷口底部組織充血傷口上皮化:細胞更新上表皮細胞組織化疤痕組織的重塑1st2nd3rd4th傷口癒合四階段1st stage: “Cleaning” the wound 止血發炎期表皮層wound healing發炎反應是傷口癒合最佳環境為其他癒合階段做好準備真皮層臨床症狀:紅腫、水腫、局部疼痛1st2nd3rd4th傷口癒合四階段1st stage: “Cleaning” the wound止血發炎期Duration: 1 to 3 daysHemostasis phase 止血期BLEEDING STOPSFormation of a clot of blood which dries and forms a scab.傷口處血液凝結止血表皮層Inflammation phase 發炎期INFLAMMATION AND "CLEANSING“ BY THE IMMUNESYSTEM 免疫系統開始發炎反應並清理傷口>> Histamine release 組織胺釋放‐ Increased permeability of blood vessels提升血管的滲透性‐ Release of white blood cells in the scarring area釋放白血球細胞至受傷區域>> Release of leukotoxins by the white blood cells白血球釋放’白細胞毒素‘‐ Elimination of all foreign bodies present in the area移除並消滅所有外在物質真皮層1st2nd3rd4th傷口癒合四階段2nd stage: Granulation 肉芽生長期表皮層真皮層在此階段, 傷口呈粉紅色, 肉芽組織出現新的血管形成臨床症狀:傷口底部組織充血1st2nd3rd4th傷口癒合四階段2nd stage: Granulation 肉芽生長期Granulation phase 肉芽生長期Duration: 1 week增殖表皮層纖維母細胞及血管增殖細胞外基質增生真皮層中的支撐型纖維形成真皮層肉芽組織生成由膠原蛋白纖維及毛細血管組成的組織形成, 並有效保護傷口免於感染> Link of each edges until a total closure表皮細胞從四周移入，形成單一細胞層，把受傷皮膚的表面覆蓋住1st2nd3rd4th傷口癒合四階段3rd stage: Epithelialization上皮生長期表皮層The purpose of this stage is to resurfaceand impart strength to the wound此階段的目的是幫助傷口填補表面, 並給予傷口足夠的力量真皮層臨床症狀:傷口表皮化－細胞更新1st2nd3rd4th傷口癒合四階段3rd stage: Epithelialization上皮生長期Epithelialization phase 上皮生長期Duration: 1 to 3 weeks上皮化表皮層Epithelial cells: 上皮細胞角質細胞上移, 增生, 分化覆蓋肉芽組織真皮層Fibroblasts: 纖維母細胞重建表皮層與真皮層的交界處(DEJ)1st2nd3rd4th傷口癒合四階段4th stage: Remodeling 疤痕重塑期up to 18 months表皮層在纖維母細胞的影響下傷口疤痕會逐漸變淺, 變平滑真皮層臨床症狀:上表皮細胞組織化，疤痕組織的重塑1st2nd3rd4th傷口癒合四階段4th stage: Remodeling 疤痕重塑期Remodeling phase 疤痕重塑期Duration: up to 18 weeksMATURATION OF COLLAGEN FIBRES 膠原纖維已成熟> Transformation of type III collagen fibers to type I膠原蛋白纖維由第3型轉換為較具張力及支撐力的第1型> High rate of collagen synthesis纖維母細胞重新分泌較細緻的膠原蛋白纖維表皮層> Improvement of the dermis‘s mechanical properties提升真皮層組織的機能性與強韌度真皮層CONTRACTION OF THE SCAR 疤痕組織收縮> Transformation of granulation tissue into scar tissue肉芽組織轉換為更為緊實的疤痕組織傷口癒合四階段DAY 60+傷口程度較表淺傷口程度較深層1st stage:2nd stage:3rd stage:Epithelialization上皮生長期4th stage:Remodeling疤痕重塑期Cleansing the wound Granulation止血發炎期肉芽生長期醫美產品輔助角色保護傷口先止血紅腫水腫局部疼痛修復保濕上表皮細胞組織化疤痕組織的重塑傷口底部傷口表皮化:加速傷口的修復速度提升傷口的修復品質 美化疤痕, 避免疤痕產生Cicaplast Range產品區隔 The3mostimportantstepsforwoundrepairing:Wound typesProtecting保護Repairing修復Moisturizing保濕Post-Procedure(傷口程度較深層)GELChronic skin wound(傷口程度較表淺)Daily injuries(傷口程度較表淺)B5* Professional advice from Dr.邱品齊Cicaplast Range產品適用範圍 / 區分1適應症日常偶發性傷口及不適2慢性發炎傷口3Post-procedure術後傷口Dailyinjuries皮膚灼熱.乾燥.搔癢.粗糙; 皮膚龜裂.裂紋; 蚊蟲咬; 擦. 切. 劃. 曬傷;泡疹; 日光性皮膚炎Chronicskin wound濕疹; 異位性皮膚炎;皮膚乾燥症; 尿布疹;脂漏性皮膚炎; 乾癬雷射手術後; 換膚後;脈衝光後; 磨皮後諮詢對象自我診斷/藥師NEW BAUME B5 皮膚科醫師/藥師皮膚科醫師/藥師GEL價格接受度瘢痕速效保濕修復凝膠CICAPLAST BAUME B5全面修復霜立即舒緩. 全面修復各類問題皮膚的不適及傷口避免疤痕產生有效成分 PANTHENOL 5%維生素原B5 MADECASSOSIDE 積雪草苷 Traceelements Cu/Zn/Mn微量元素 銅/鋅/錳 SHEABUTTER 雪亞脂[精簡配方, 溫和、有效]適合居家常備、隨身攜帶使用嬰兒. 小孩. 成人身體及臉部適用適用範圍Chronic skin wound 慢性發炎傷口濕疹; 異位性皮膚炎; 皮膚乾燥症; 尿布疹; 刺激性皮膚炎.脂漏性皮膚炎; 乾癬Daily / occational injuries 日常偶發性傷口及不適皮膚灼熱.乾燥.搔癢.粗糙; 皮膚龜裂.裂紋; 蚊蟲咬; 擦. 切.劃. 曬傷; 泡疹; 日光性皮膚炎CICAPLAST BAUME B5主成分INGREDIENTSPANTHENOL 5%維生素原B5PROPERTIES> 修復 Stimulates epithelialization & fibroblastsproliferation> 舒緩 Soothes & Anti-inflammatory> 修復 Stimulates cells renewal &Stimulates dermis fibrous renewal> 抗發炎 Soothes & Anti-inflammatory> 抗菌 Anti-bacterial adhesion> 修復 Stimulates cells renewal> 抗菌 Antimicrobial> 重建皮脂膜 Rebuilds cutaneous barrier> 舒緩 Brings cutaneous comfort> 保濕 Hydrates> 保濕 HydratesMADECASSOSIDE 積雪草苷 0.3%Trace elements 微量元素 銅/鋅/錳COPPER GLUCONATE0.01%ZINC GLUCONATE0.01%MANGANESE GLUCONATE 0.01%SHEA BUTTER 雪亞脂 5%GLYCERIN 甘油LRP THERMAL SPRING WATER 溫泉水> 舒緩 SoothesPANTHENOL 維生素原B5主要功效Stable biological form of Vitamin B5With the same concentration as a medicine:[PANTHENOL5%]泛醇, 亦稱Pro-Vitamin B5 (維生素原B5)or Dexpanthenol(右泛醇)or D-Panthenol,為維生素B5(泛酸)的前體, 是一種具有生物活性的B群維生素, 在體內活細胞泛醇會轉化為泛酸PROPERTIES修復舒緩> Stimulates epithelialization刺激上皮生長> Activates fibroblasts proliferation促進纖維母細胞增生> Controls inflammatory mechanisms by reducing pro-inflammatory mediators release抑制發炎反應傳導因子釋出, 控制發炎反應PANTHENOL 維生素原B5Literature clinical dataEfficacy of Panthenol in improving the wound healing processPROTOCOL維生素原B5促進傷口癒合修復過程的效果修復> Double-blind vs. placebo study> 15 male patients> Water-in-oil emulsion with 5% of Panthenol> Daily application during 5 days> Assessment of excised wound tissue by ultrasound and histologic examinationRESULTS> Wounds treated with Panthenol has significant: erythemareduction 紅腫減少 moreelasticandsolidtissueregeneration 更多有彈性及結實的組織再生> Histologically, Panthenol was effective in stimulating the healing process維生素原B5可有效促進傷口癒合修復的過程Pugliese PT, Farina JC, Chautems YEfficacy of dexpanthenol in wound healing: double-blind assessment of excised wound tissue by ultrasound and histologic examination.Nouv Dermatol 1995; 14: 130-138 [Bepanthene© Hoffmann La Roche Ltd]PANTHENOL 維生素原B5Literature clinical dataClinical proofs of efficacy修復Numerous dermatological studies (Europe, US -Leder, Steumannetc.) have proven that D-panthenol helps skin to «heal». It reinforces quickly epithelium, but also the skin capacity toretain water what improves skin tonicity. The Topical use of Panthenol acts as a moisturizer, whileimproving the hydration of superficial layers reducing the imperceptible water loss(IWL) andimproving the maintain of skin softness and elasticity.文獻指出維生素原B5可有效：加速上皮生長 減少IWL(難察覺的水份流失) 提升皮膚柔軟及彈性The activation of keratinocytes proliferation has been observed in vitro and in vivo withPanthenol, what has a great interest in the wound healing process. The re-epithelialisation issped up, the wound healing process is controlled thanks to the imperceptible water loss as agood indicator for the functioning of the epidermical barrier function.In vitro & vivo 觀察到維生素原B5可有效刺激角質細胞增生, 十分有助於傷口癒合修復過程：再上皮化加速, 改善皮脂膜功能,減少IWL, 進而控制傷口癒合的過程Ebner F, Heller A, Rippke F, Tausch I : Topical use of Dexpanthenol in Skin Disorders: Am.J. Clin, Dermatol.: 2002: Vol 3: (6): pp 427-433PANTHENOL 維生素原B5Literature clinical dataClinical proofs of efficacy舒緩The Panthenol benefits have been observed on patients after a skin transplant or scar healing orduring therapeutic treatments of burns of others dermatitis.維生素原B5的的功效在皮膚移植後或疤痕癒合中或有灼熱感的皮膚炎的患者身上可觀察到The stimulation of epithelialization, the diminution in itching have been the most notableeffects of formulas with Panthenol. 特別是“刺激上皮化”及“減少瘙癢感”的功效In double-blind vs. placebo studies, Panthenol has been evaluated for its efficacy on wound-healing. Epidermical injuries which have been treated with an emulsion containing Panthenolshow a reduction in erythema and an increased regeneration of elastic tissues. The follow up ofimperceptible water loss shows the significant acceleration in epidermical regeneration followinga Panthenol-based therapy vs. placebo.Symptoms of skin irritation such as skin dryness, roughness, desquamation, erythema, pruritdecrease after 3-4 weeks.在雙盲測試下, 維生素原B5助於傷口癒合的功效評估： 減少紅腫 提升彈性組織的再生 加速表皮再生 減少皮膚刺激不適的症狀, 含乾燥, 粗燥, 脫屑, 紅腫, 瘙癢感Ebner F, Heller A, Rippke F, Tausch I : Topical use of Dexpanthenol in Skin Disorders: Am.J. Clin, Dermatol.: 2002: Vol 3: (6): pp 427-433MADECASSOSIDE 積雪草苷起源 & 發展源自於“積雪草”(Titrated Extract ofCentella Asiatica)發現3種有效結構促進傷口癒合主要的藥物成分發現積雪草中最有效的萃取物:成功萃取出95%極高純度Madecassoside的MadecassosideMADECASSOSIDE 積雪草苷主要功效來源> 積雪草 (Centella Asiatica)的萃取物> 95% 極高之有效純度PROPERTY修復> Stimulates epithelializationimprovedkeratinocytesorganizationandhigh-qualityrepair刺激上皮化,改善角質細胞組織及高品質的修復>Regulateskeratinocyterenewalanddifferentiation規則化角質細胞的再生與分化>FightinflammationfactorsModeratesthereleaseofinflammationfactors:Interleukines,Prostaglandines(PGE2) 有效抗發炎: 抑制發炎反應傳導因子釋出, 如Interleukines & PGE2> Anti-bacterial adhesion 抗菌抗發炎抗菌MADECASSOSIDE 積雪草苷A randomized double-blind clinical study of AD lesion treatmentMadecassoside改善異位性皮膚炎傷口之double blind clinical studyPROTOCOL修復> 對象: 80位3-12歲, 患有異位性皮膚炎的兒童 (平均SCORAD=39)> 隨機分配使用: 含有0.3%Madecassoside的乳霜 或不含有0.3%Madecassoside的乳霜> 每天至少使用2次在異位性皮膚炎傷口, 連續使用30天 (期間全身皆有使用相同保濕劑)> 在D0, D42, D84由皮膚科醫師盲測SCORAD, 搔癢及睡眠品質指數RESULTS> 使用含0.3%Madecassoside的乳霜的群組,在D42及D84時, SCORAD分別減少30%及53%-30%-53%> SCORAD (“SCORing Atopic Dermatitis”) 評估異位性皮膚炎的臨床工具, 以數值方式評估病情程度,嚴重程度佔60% , 病灶範圍佔 20%, 主觀症狀佔20%S. SEITE1, A. ROUGIER1, H. ZELENKOVA21La Roche-Posay Dermatological Laboratories, Asnières, France; 2Department of Dermatovenereology, Svidnik, SlovakiaMADECASSOSIDE 積雪草苷A randomized double-blind clinical study of AD lesion treatmentMadecassoside改善異位性皮膚炎傷口之double blind clinical studyRESULTS> 使用含0.3%Madecassoside的乳霜的群組, 其搔癢及睡眠不足的強度, 亦較為顯著的被改善搔癢感眠眠不足修復TRACE ELEMENTS: Zn/Cu/Mn 微量元素 鋅/銅/錳主要功效ELEMENTS> ZINC [Zn] 鋅> COPPER [Cu] 銅> MANGANESE [Mn] 錳PROPERTIES修復抗菌> Stimulate new cells production促進新生細胞的形成> Stimulate wound healing mechanisms促進傷口癒合過程機轉> Combined action on the reduction of the development of bacteria抑制細菌增生TRACE ELEMENTS: Zn/Cu/Mn 微量元素 鋅/銅/錳In vitro data鋅/銅/錳, 促進新生細胞的形成PROTOCOL> In vitro keratinocytes culture> Monolayer of cells was scratched in astandardized manner with a plastic apparatusto create a cell-free zone> Adjunction of water or trace elements→ zinc gluconatecopper gluconatemanganesegluconate>Measurementismonitoredbytherepopulationoftheclearedareawithcellsovertime.在體外培養的角質細胞環境下使用塑膠設備,標準化的將單層細胞刮開,形成“cell-free zone”隨著時間,量側評估cell-freezone新生細胞的形成狀況(Zn/Cu/MncomparetoControl[=water])Tenaud I., Leroy S., Chebasseir N. and Dreno B.Zinc, copper and manganese enhanced keratinocyte migration through a functionalmodulation of keratinocytes integrins. Exp. Dermatol. 2000, 9(6):407-416RESULTS修復> Keratinocytes covered a greater area inpresence of the trace elements vs the control微量元素鋅/銅/錳新生細胞形成速度較控制組快許多120100%806040* * *2000hrControlCu gluconate 2 µg/ml6hr24hr48hrZn gluconate 1.8 µg/mlMg gluconate 1 mg/ml(*P<0.01) compared with that of control medium -Student’s t-test)TRACE ELEMENTS: Zn/Cu/Mn 微量元素 鋅/銅/錳In vitro data鋅/銅/錳, 促進傷口癒合過程機轉修復RESULTS> Integrins α2 and α6 expressions arestimulated in presence of the trace elements= re-epithelialization induction鋅/銅/錳刺激Integrins (α2, α6) expression, 誘發再上皮化現象, 促進傷口癒合過程α2 expression12%CONTEXT> Integrins (α2, α6) expression in the epidermisare modified during the re-epithelialization在再上皮化時, 表皮層中的Integrins (α2, α6)expression會有變化PROTOCOL> In vitro keratinocytes culture> Adjunction of trace elements→ zinc gluconate copper gluconatemanganese gluconate> Integrin's expression was evaluated byimmunohistochemistry.在體外培養的角質細胞環境下以免疫組織化學染色法,評估鋅/銅/錳對於Integrins(α2, α6) expression的影響(compare to Control)Tenaud I., Sainte Marie I., Jambou O., Lipoux P. and Dreno B.In vitro modulation of keratinocyte wound healing integrins by zinc, copper andmanganese. Br. J Dermatology, 1999, janv; 140(1):26-34α6 expression504030108642201000(*P<0.05)compared with that of control mediumSHEA BUTTER 雪亞脂主要功效Produced by mechanical extraction (vs. chemical extraction)→ Better tolerance “pure” product 純度高, 較好的耐受性→ Preserves all active agents 維持成分有效性物理性萃取而成 (vs.化學性萃取）> Advantages of extraction by mechanical pressure: 物理性萃取優點> Disadvantage of chemical extraction using solvents: 化學性萃取缺點→ Risk of intolerance due to chemical solvent residues 由於化學溶劑的殘留, 易有敏感的風險修復 > Strong LIPID-REPLENISHING action 重建皮脂膜> Soothe skin irritation & tightness 舒緩皮膚不適舒緩PROPERTIE:Lodén M, Andersson AC.Effect of topically applied lipids on surfactant-irritated skin.Br J Dermatol. 1996 Feb;134(2):215-20.SHEA BUTTER 雪亞脂重建皮脂膜 雪亞脂主要由脂肪酸類組成,雪亞脂中的脂肪酸類的比例和皮膚中的極為相似,因此可提供皮膚最佳的脂肪酸類補充, 且這些脂肪酸亦十分有助於重建皮膚皮脂膜, 強化皮膚屏障功能 (skin barrier) 雪亞脂富含的脂肪酸類:>>>>油酸 Oleic acid (45%):具舒緩功效, 可促進親水性物質滲透進皮膚結構, 預防膽固醇的生物合成(皮膚屏障功能)硬脂酸Stearic acid (42%):也具舒緩功效, 幫助提升皮膚屏障功能亞麻油酸Linoleic acid (6%):是組成及維持皮膚屏障功能必須的脂肪酸, 也有重要的舒緩作用棕櫚酸Palmitic acid (4%):是皮脂腺細胞用來合作皮脂腺蠟的脂肪酸.調節膽固醇的生物合成(是皮膚屏障主要功能). 是角質細胞再生的必須脂肪酸CLINICAL TESTCICAPLAST BAUME B5France Observational StudyPROTOCOL 共測試在 18 種不同的適應症 (下頁說明) 測試病患條件:••6 個月以上的男女性, 並有表皮的傷口 (也含因醫美術後造成的傷口)不含以下條件的病患: 有二次發炎的傷口; 濕潤的傷口; 傷口有滲出液; 傷口使用過或正在使用其他表皮性治療•共有 2,243 位病患參與測試含 547 位兒童(平均年齡 3.5 歲), 及 1,696 位成人(平均年齡 46.5 歲) 產品測試方法:•共 379 位醫師參與 (含 283 位皮膚科醫師, 96 位小兒科醫師), 每位醫師招募 6 位病患••D0: 醫師填寫評估表, 並處方CICAPLAST BAUME B5全面修復霜D15-30: 每天早晚使用2次, 持續約2-4週*, 並由病患及醫師一同進行病症評估*依照病情程度不一, 一半的病患使用18天, 另一半的病患持續使用直到傷口消失CICAPLAST BAUME B5France Observational StudyForinfants,childrenandadultsFormultipleindications刺激性皮膚炎冷凍治療後濕疹皮膚灼熱刺激性易乾裂的皮膚炎尿布疹唇炎雷射術後皮膚龜裂&裂痕口角炎皮膚乾燥症磨皮後皮膚龜裂電凝術後蚊蟲咬泡疹後磨皮後日光性皮膚炎CICAPLAST BAUME B5France Observational Study有效性有效改善臨床症狀flaking- 75%病患, 皮膚脫屑症狀完全消失有效改善主觀不適症狀 - 74%病患, 皮膚裂痕症狀完全消失安全性-85%-77%-84%-80%98%病患滿意產品安全性(約2200人)灼熱感刺痛感疼痛瘙癢CICAPLAST BAUME B5安全性- 測試於700位病患安全性測試於嬰兒, 兒童, 成人PROTOCOL>Occlusive repeated patch test貼布測試>小兒科及皮膚科醫師監控下>520 敏感性皮膚病患 +52 異位性皮膚炎病患PROTOCOL> 每天使用2次, 連續使用4週>小兒科及皮膚科醫師監控下>52 位4-34個月的嬰兒 +75 位有異位性皮膚炎的成人RESULTS>No irritation 無刺激現象>No sensitivity 無敏感現象RESULTS>Good tolerance 極佳耐受性CICAPLAST BAUME B5精簡配方, 極高安全性香精Paraben類防腐劑羊毛脂鄰苯二甲酸酯CICAPLAST BAUME B5極舒適質地CICAPLAST BAUME B5全面修復霜立即舒緩. 全面修復各類問題皮膚的不適及傷口避免疤痕產生溫和、有效適合居家常備、隨身攜帶使用NT$400/40ml適用範圍嬰兒. 小孩. 成人 / 身體及臉部適用Chronic skin wound 慢性發炎傷口濕疹; 異位性皮膚炎; 皮膚乾燥症; 尿布疹; 刺激性皮膚炎. 脂漏性皮膚炎; 乾癬Daily / occational injuries 日常偶發性傷口及不適皮膚灼熱.乾燥.搔癢.粗糙; 皮膚龜裂.裂紋; 蚊蟲咬; 擦. 切. 劃. 曬傷;泡疹; 日光性皮膚炎使用方式待傷口呈乾燥狀況(dry lesion), 無任何組織液流出時, 即可塗抹適量於患處[ 醫美術後必備 ]有效成分CICAPLAST GEL瘢痕速效保濕修復凝膠保護醫美術後皮膚加速傷口修復速度避免疤痕產生 MADECASSOSIDE 積雪草苷 PANTHENOL 維生素原B5 Traceelements Cu/Zn/Mn微量元素 銅/鋅/錳 Dimethicone 聚二甲基矽氧烷適用範圍Post procedure 醫美術後雷射手術後; 換膚後; 脈衝光後; 磨皮後, 電波拉皮後; 冷凍治療後CICAPLAST GEL主成分INGREDIENTSMADECASSOSIDE 積雪草苷 0.3%PROPERTIES> 修復 Stimulates cells renewal &Stimulates dermis fibrous renewal> 抗發炎 Soothes & Anti-inflammatory> 抗菌 Anti-bacterial adhesion> 修復 Stimulates epithelialization & fibroblastsproliferation> 舒緩 Soothes & Anti-inflammatoryPANTHENOL 維生素原B5 1%Trace elements 微量元素 銅/鋅/錳COPPER GLUCONATE 0.04%ZINC GLUCONATE 0.04%MANGANESE GLUCONATE 0.02%Dimethicone 聚二甲基矽氧烷SODIUM HYALURONATE 玻尿酸GLYCERIN 甘油LRP THERMAL SPRING WATER 溫泉水> 修復 Stimulates cells renewal> 抗菌 Antimicrobial> 保護 Dressing-like texture> 保濕 Hydrates> 保濕 Hydrates> 舒緩 SoothesCICAPLAST GEL獨特傷口修復功效1. Protective action 保護Dressing-like texture 似敷料效果的質地with Dimethicone 聚二甲基矽氧烷(FDA approved silicon, topical silicone, inspired by silicone dressings) Protectivefilm 保護薄膜:isolate the affected area, limits entrance of irritating agents,create a moist environment favorable to healing 隔離傷口,避免微有機體或髒污污染傷口, 且創造濕潤的環境有助於癒合隔離髒污及灰塵氣體交換CO2 Semi-occlusive 半閉塞效果:lets the skin breathe with gaseous exchanges, preventmaceration 可產生氣體交換讓皮膚呼吸, 避免浸漬產生O2 Water-resistant 防水性:increase persistence, stays longer on the skin可維持較長時間停留於皮膚上CICAPLAST GEL獨特傷口修復功效2. Repairing action修復微量元素銅/鋅/錳促進角質細胞更新速度加速傷口癒合積雪草苷促進角質細胞分化再生提供表皮組織規則化加速傷口癒合品質CLINICAL TESTCICAPLAST GEL有效性測試Accelerates the healing process 加速癒合過程PROTOCOL“Suction bubble” method> Random blind study carried out by the Saint-Jacques UniversityHospital Centre, Dermatology Department, bBesançon FRANCE) > 12 patients, duration of 22 days> Creation of an artificial epidermal wound by “Suctionbubble” methodEVALUATIOND1第1階段D3D5D8D12• CICAPLAST 1/day + Dressing• No treatment + DressingSpeed of the healing process測量癒合速度Fringe projection technique:recreating the wound surfacedigitally第2階段D16D22• CICAPLAST 1/day• No treatmentQuality of the healing傷口癒合的品質Measuring Imperceptible Lossof Water測量水分經表皮散失的速度TREATMENTSMEASURMENTOBJECTIVEMETHOD OFEVALUATIONSkinbrokenawaybyvacuumextractionBlocksof3bubblesobtainedTopofbubblescutoffCICAPLAST GEL有效性測試RESULTS Acceleratedhealing 加速傷口癒合A gain of 2 days in healing over the 4 first days皮膚科醫師評分CICAPLASTGELUntreated Betterqualityhealing 較佳癒合品質From the 12th day, the barrier function has beenrestored測量水分經表皮散失的速度CICAPLASTGELUntreated很明顯TEWL標準值不明顯 Excellenttolerance 極佳安全性No side effects recordedCICAPLAST GEL傷口癒合速度測量CICAPLAST GEL安全性測試－醫美術後Observational study on post-procedures applicationPROTOCOL> 7 European countries - 384 dermatologists - 3 712 patients> In average, 2 applications per day for 18 days.RESULTS> Demonstrated EFFICACY and TOLERANCE on numerous indications:→ Post-aesthetic procedures 醫美手術後– Superficial / Medium peel 中淺層磨皮– Vascular laser 血管雷射在數種不同的手術後(含醫美)顯現產品有效性及安全性→ Post-dermatological acts 皮膚科治療後– Surgery with or without stitches 手術後(含有縫線及無縫線)– Cryotherapy 冷凍治療– Electrocoagulation 電凝療法CICAPLAST GEL瘢痕速效保濕修復凝膠保護醫美術後皮膚加速皮膚修復速度避免疤痕產生適用範圍小孩. 成人 / 臉部適用Post-procedure 醫美術後雷射手術後; 換膚後; 脈衝光後; 磨皮後, 電波拉皮後術後保養照護, 使用產品時程建議術後可立即保養手術1~3天後使用手術3~5天後使用IPL脈衝光, C6淨膚雷射,淺層換膚血管雷射, 凝固型飛梭雷射,電波拉皮氣化型飛梭雷射,除斑雷射使用方式NT$650/40ml待傷口呈乾燥狀況(dry lesion), 無任何組織液流出時, 即可塗抹適量於患處CICAPLAST RANGECicaplast Range產品適用範圍 / 區分1適應症日常偶發性傷口及不適2慢性發炎傷口3Post-procedure術後傷口Dailyinjuries皮膚灼熱.乾燥.搔癢.粗糙; 皮膚龜裂.裂紋; 蚊蟲咬; 擦. 切. 劃. 曬傷;泡疹; 日光性皮膚炎Chronicskin wound濕疹; 異位性皮膚炎;皮膚乾燥症; 尿布疹;脂漏性皮膚炎; 乾癬雷射手術後; 換膚後;脈衝光後; 磨皮後諮詢對象自我診斷/藥師NEW BAUME B5 皮膚科醫師/藥師皮膚科醫師/藥師GEL價格接受度瘢痕速效保濕修復凝膠Cicaplast Baume B5Product comparison: vs. Cicaplast gelNEW全面修復霜適應症所有日常偶發性傷口及不適及慢性發炎傷口瘢痕速效保濕修復凝膠醫美術後目標族群主訴求嬰兒. 兒童. 成人 身體及臉部適用立即舒緩. 全面修復各類問題皮膚的不適及傷口避免疤痕產生極舒適質地, 滋潤保濕, 推開後迅速吸收不黏膩, 不留下白色痕跡•修復: 5% 維生素原B5+ 積雪草苷 + 銅/鋅/錳保濕: 雪亞脂兒童. 成人 臉部適用保護醫美術後皮膚加速傷口修復速度避免疤痕產生特殊保護薄膜質地, 透氣不透水••保護: Dimethicone (似敷料效果質地)修復: 積雪草苷 + 維生素原B5+ 銅/鋅/錳質地主成分+作用容量•40 ml40 mlCicaplast Baume B5Product comparison: vs. Lipikar APNEW全面修復霜適應症所有日常偶發性傷口及不適及慢性發炎傷口理必佳異位修護滋養霜異位性皮膚炎膚質或極乾燥膚質主訴求立即舒緩. 全面修復各類問題皮膚的不適及傷口避免疤痕產生極舒適質地, 滋潤保濕, 推開後迅速吸收不黏膩, 不留下白色痕跡極度溫和 長效保濕有效舒緩因乾燥引起的皮膚癢舒適且不油不膩的乳霜質地,強效滋潤,吸收滲透迅速,質地主成分+作用容量搭配用法••修復: 5% 維生素原B5+ 積雪草苷 + 銅/鋅/錳保濕: 雪亞脂•••修護皮脂膜: 雪亞脂 +芥子油保濕: 雪亞脂止癢: 菸鹼醯胺40 ml200/400 ml避開傷口處, 全身使用AP作為保濕劑; 針對局部乾燥傷口處, 使用B5修復傷口CICAPLAST BAUME B5 全面修復霜全成分表Cicaplast Baume B5成分中文作用1234567891011121314151617181920212223AQUA / WATERHYDROGENATED POLYISOBUTENEDIMETHICONEGLYCERINBUTYROSPERMUM PARKII BUTTER / SHEA BUTTERPANTHENOLBUTYLENE GLYCOLALUMINUM STARCH OCTENYLSUCCINATEPROPANEDIOLCETYL PEG/PPG-10/1 DIMETHICONETRISTEARINZINC GLUCONATEMADECASSOSIDEMANGANESE GLUCONATEMAGNESIUM SULFATEDISODIUM EDTACOPPER GLUCONATEACETYLATED GLYCOL STEARATEPOLYGLYCERYL-4 ISOSTEARATESODIUM BENZOATEPHENOXYETHANOLCHLORHEXIDINE DIGLUCONATECI 77891 / TITANIUM DIOXIDE水氫化聚異丁烯皮膚柔潤劑矽靈防水劑甘油柔軟、保濕劑雪亞脂滋潤劑維生素原B5能刺激細胞分裂再生並組織修復丁二醇保濕劑澱粉辛烯基琥珀酯鋁鹽吸附劑1,3-丙二醇溶劑鯨蠟基聚乙醇W/O型乳化劑三硬脂精皮膚柔潤劑葡糖酸鋅肌膚調理劑積雪草萃取物能幫助肌膚組織再生葡糖酸錳肌膚調理劑硫酸鎂增量劑乙二胺四乙基二鈉螯合劑葡糖酸銅肌膚調理劑乙醯化乙二醇硬脂酸酯皮膚柔潤劑聚甘油-4 異硬脂酸酯乳化劑苯甲酸鈉防腐劑苯氧乙醇防腐劑氯己定二葡糖酸鹽防腐劑二氧化鈦不透明劑CICAPLAST GEL 瘢痕速效保濕修復凝膠全成分表成分AQUA / WATERGLYCERINCYCLOPENTASILOXANECYCLOHEXASILOXANEDIMETHICONEC30-45 ALKYL DIMETHICONESODIUM CITRATEPEG/PPG-18/18 DIMETHICONEPANTHENOLZINC GLUCONATEMADECASSOSIDEDIMETHICONOLMANGANESE GLUCONATESODIUM HYALURONATEDISODIUM EDTACOPPER GLUCONATECITRIC ACIDPOLYSORBATE 20SODIUM BENZOATE12345678910111213141516171819Cicaplast gel中文水甘油環戊矽氧烷環己矽氧烷矽靈C30-45 烷醇二甲基聚矽氧烷檸檬酸鈉PEG/PPG-18/18 聚二甲基矽氧烷維生素原B5葡糖酸鋅積雪草萃取物聚二甲基矽氧烷醇葡糖酸錳玻尿酸鈉乙二胺四乙基二鈉葡糖酸銅檸檬酸聚山梨醇酯 20苯甲酸鈉作用柔軟、保濕劑滑順劑滑順劑防水劑滑順劑酸度調節劑矽質稠化劑能刺激細胞分裂再生並組織修復肌膚調理劑能幫助肌膚組織再生柔軟劑肌膚調理劑強效保濕劑螯合劑肌膚調理劑酸鹼調節劑界面活性劑防腐劑
